This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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187
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Type:
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Contributed
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Date/Time:
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Monday, August 2, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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Abstract - #306625 |
Title:
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Sample Size Requirement in Clustered Matched-Pair Design for Noninferiority Test
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Author(s):
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Jun-mo Nam*+
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Companies:
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National Cancer Institute
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Address:
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EPS/8028, 6120 Executive Blvd, Rockville, MD, 20852-7244,
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Keywords:
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clustered matched-pair ;
non-inferiority ;
power ;
sample size
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Abstract:
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Consider clustered matched-pair studies for non-inferiority where clusters are independent but units in a cluster are correlated and an inexpensive new method and the expensive standard one are applied to each unit. Proper test statistics for non-inferiority have recently developed by Durkalski etal and Nam and Kwon. In this paper, we investigate power and sample size requirement of a clustered matched pair study for non-inferiority. Power of a test is primarily related to the number of clusters and the effect of a cluster size on power is secondary. A cluster size of more than four has little or no effect in reducing the number of clusters for a given power. We provide a formula for the number of clusters given cluster size and the cluster size given number of clusters for a specific power. An example involving sample size requirement of a clustered matched-pair study is illustrated.
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Authors who are presenting talks have a * after their name.
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