This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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452
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 4, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #306568 |
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Title:
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Model Selection and Hypothesis Testing for Case-Control Genetic Association Studies
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Author(s):
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Jinfeng Xu*+ and Gang Zheng and Ao Yuan
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Companies:
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National University of Singapore and National Institutes of Health and Howard University
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Address:
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, Singapore, 117546,
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Keywords:
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Case-control ;
Genomwide association studies ;
model selection ;
Hypothesis testing ;
genetic model uncertainty ;
complex diseases
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Abstract:
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Case-control genetic association studies have been shown to be effective in identifying disease-related genes in many complex diseases. One major challenge in testing genetic association is due to the gentic model uncertainty. In this article, we first consider several different criteria for the comparison of some existing approaches and then a new method is proposed and shown to exhibit good properties. Finally, simulation studies as well as real data applications are used to illustrate the proposed methodology.
This is joint work with Gang Zheng from National Heart, Lung and Blood Institute and Ao Yuan from Howard University.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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