This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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329
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 3, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #306467 |
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Title:
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Optimal Crossover Designs for PK Studies
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Author(s):
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Sergei Leonov*+ and Valerii Fedorov and Byron Jones
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Companies:
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GlaxoSmithKline and GlaxoSmithKline and Pfizer Inc.
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Address:
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1250 South Collegeville Rd, Collegeville, PA, 19426,
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Keywords:
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cross-over trials ;
compartmental models ;
optimal design ;
random effects ;
sampling times
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Abstract:
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Cross-over trials are often used to estimate the PK profile of a drug when healthy subjects receive alternative doses of the drug in successive periods of time. The design of cross-over trials requires an optimal choice of the dose sequences and sampling times within each period. We describe new results for choosing the sampling times which are based on optimal experimental design theory for nonlinear models with multiple responses, random coefficients, and which relies on biological compartmental models
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