This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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144
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Type:
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Invited
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Date/Time:
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Monday, August 2, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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International Indian Statistical Association
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Abstract - #306268 |
Title:
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Improve the Accuracy of Calling Short CNVs in Genomewide Association Studies
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Author(s):
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Jianxin Shi*+
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Companies:
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National Cancer Institute
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Address:
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, Rockville, MD, 20852,
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Keywords:
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genome-wide association studies ;
copy number variants ;
linkage disequilibrium
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Abstract:
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Germline copy number variants (CNVs) were reported to be associated with many complex diseases including cancers. However, the accuracy of calling short CNVs based on GWAS genotyping platforms is not satisfying, particularly when the scientific goal is to identify rare and highly penetrant CNVs associated with complex diseases. In this talk, we will discuss two strategies that may potentially improve the accuracy of calling short CNVs. The first approach aims to account for the linkage disequilibrium when modeling B-allele frequencies. This strategy is particularly useful for calling short deletions. The second approach aims to model the relatedness among subjects and it can be applied in both family-based genetic studies or population-based genetic studies. The application to GWAS of cancers will be be presented.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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