This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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599
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Type:
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Invited
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Date/Time:
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Thursday, August 5, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistical Learning and Data Mining
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Abstract - #306262 |
Title:
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P-Values or Prediction Errors: What Is the Name of the Game in Genomics?
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Author(s):
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Rafal Kustra*+
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Companies:
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University of Toronto
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Address:
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Dalla Lana School of Public Health, toronto, ON, m5t 3m7, Canada
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Keywords:
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statistical genomics ;
Receiver Operating Curve ;
Multiple Testing Problem ;
Sensitivity
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Abstract:
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In this talk we consider a (now) ubiquitous multiple testing problem (MTP) of genomics. In majority of cases the genomics experiment is considered an exploratory step that: 1) Attempts to confirm the existance of some correlation between genetic and phenotypic effetcs and 2) Suggest a further experimental roadmap. Most methods today return a sea of p-values (even if adjusted for MTP), which is rarely helpful with the two questions above. Moreover individual p-values which focus on association between single genetic effects and a common phenotype often hide the underlying complexities of the experiment and data analysis - many of which are unevenly spread across the genetic probes. In this talk we will consider whether a paradigm shift in high-throughput genomic analysis may be needed when the number of entities examined grows ever larger with technological advances.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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