This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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150
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Type:
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Invited
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Date/Time:
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Monday, August 2, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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Abstract - #306254 |
Title:
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Evaluating Markers for Treatment Selection
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Author(s):
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Xiao Song*+ and Margaret Sullivan Pepe and Xiao-Hua Zhou
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Companies:
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The University of Georgia and Fred Hutchinson Cancer Research Center and University of Washington
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Address:
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2103 Allegheny LN, Watkinsville, GA, 30677,
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Keywords:
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Biomarker ;
Selection impact curve ;
Statistical interaction
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Abstract:
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For many medical conditions several treatment options may be available for treating patients. We consider evaluating markers based on a simple treatment selection policy that incorporates information on the patient's marker value exceeding a threshold. Although traditional regression methods may assess the effect of the marker and treatment on outcomes, it is appealing to quantify more directly the potential impact on the population of using the marker to select treatment. We propose a graphical display, the selection impact (SI) curve that can be useful for choosing a treatment policy that incorporates information on the patient's marker value exceeding a threshold. We further propose the covariate specific SI curve to incorporate covariate information in treatment selection. Nonparametric and semiparametric estimators are developed accordingly.
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