This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
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Activity Number:
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643
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Type:
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Invited
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Date/Time:
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Thursday, August 5, 2010 : 10:30 AM to 12:20 PM
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Sponsor:
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Statistical Society of Australia
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| Abstract - #306191 |
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Title:
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Challenges in the Conduct of Clinical Trials in the Australasian Region
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Author(s):
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Val Gebski*+
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Companies:
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University of Sydney
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Address:
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Locked Bag 77, Camperdown , Sydney, International, 1450, Australia
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Keywords:
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Clinical trials ;
Trial design ;
Sample sizes ;
Multi-national ;
Health Services ;
Meta-analysis
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Abstract:
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Multi-national clinical trials present unique challenges if the countries to be involved in the study differ in language, culture and health services delivery and practice. Potential reasons for different treatment effects in different countries include: (i) Patient and disease characteristics such as race, genetic factors, diet; (ii) treatment delivery/quality such as surgery, complex behavioural interventions;(iii) assessment of outcome including frequency of monitoring, clinical tests, interpretation of criteria for assessment, quality of life scores.
Another challenge is the small sample sizes individual regions can contribute to a clinical question for which the clinically significant difference is modest. As a result it can be more efficient to design individual studies examining surrogate outcomes and design the main study question as a prospective meta-analysis.
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Authors who are presenting talks have a * after their name.
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