This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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2
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Type:
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Invited
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Date/Time:
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Sunday, August 1, 2010 : 2:00 PM to 3:50 PM
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Sponsor:
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WNAR
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Abstract - #306124 |
Title:
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Population-Genetic Approaches for Phylogenetic Substitution Models
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Author(s):
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Nicolas Rodrigue*+
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Companies:
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University of Ottawa
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Address:
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Department of Biology, Ottawa, ON, K1N 6N5, Canada
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Keywords:
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mutation-selection ;
Dirichlet process ;
Markov chain Monte Carlo
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Abstract:
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Modeling the interplay between mutation and selection at the molecular level is key to modern evolutionary studies. To this end, codon-based evolutionary models have been proposed as pertinent means of studying long-range evolutionary patterns. However, these approaches have not yet consolidated results from studies showing that purifying selection in proteins displays strong site-specific effects, which translate into heterogeneous amino acid propensities across the columns of alignments. In this talk, we integrate recent developments in nonparametric statistical approaches to propose a probabilistic model that accounts for the heterogeneity of amino acid fitness profiles across the coding positions of a gene. We apply the model to a dozen real protein-coding gene alignments and find it to produce biologically plausible inferences.
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The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
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