This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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603
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Type:
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Invited
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Date/Time:
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Thursday, August 5, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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WNAR
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Abstract - #306004 |
Title:
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A Random Coefficients Model for Regional Coexpression Associated with DNA Copy Number Aberrations
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Author(s):
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Wessel Van Wieringen*+
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Companies:
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VU University Medical Center
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Address:
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, Amsterdam, , The Netherlands
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Keywords:
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Bootstrap ;
Constrained estimation ;
Data integration ;
Microarray
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Abstract:
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We integrate coupled DNA copy number and gene expression data in order to study regional co-expression, i.e. the phenomenon of neighborhoods of contiguous genes showing similar expression patterns. Such neighborhoods appear throughout the cancer genome and often coincide with copy number aberrations (CNA). We use a random coefficients model to link copy number data of a genomic region to its genes' expression data. The model facilitates a global analysis of regional co-expression at the level of the region (rather than its genes) to assess whether a) there is a shared CNA effect on expression levels of genes within the region, and b) the CNA effect is identical for all genes. To estimate the parameters from high-throughput data, we optimize estimation wrt computational speed and memory use, while incorporating prior knowledge on the parameters. Two examples illustrate the methodology.
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Authors who are presenting talks have a * after their name.
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