This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
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107
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Type:
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Invited
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Date/Time:
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Monday, August 2, 2010 : 8:30 AM to 10:20 AM
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Sponsor:
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Committee on Applied Statisticians
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Abstract - #305956 |
Title:
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Simpson's Paradox: Aggregating and Partitioning Populations in Health Care Disparities of Lung Cancer Patients
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Author(s):
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Pingfu Fu*+ and Mark Schluchter and Rom Leidner and Balazs Halmos
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Companies:
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Case Western Reserve University and Case Western Reserve University and Case Western Reserve University and Columbia University Medical Center
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Address:
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10900 Euclid Avenue, Cleveleand, OH, 44106, usa
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Keywords:
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Simpson's paradox ;
homogeneity ;
lung cancer ;
separation of logistic regression ;
EGFR FISH ;
EGFR mutation
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Abstract:
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In the development of targeted therapeutic agents, attempts including novel designs and other strategies to better characterize tumors with the goal of finding more specific therapies that are tailored to a particular tumor type as determined by molecular and genetic signatures continue to play a big role. Statistical inferences based on aggregating and partitioning data may have contradicting conclusions. We give a real life example regarding genetic abnormalities of the EGFR pathway in patients with Non-Small Cell Lung Cancer and deal with it using the methods that solve the problem of separation in logistic regression.
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