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Activity Number:
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378
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #305488 |
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Title:
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Modeling Three-Dimensional Chromosome Structures Using Gene Expression Data
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Author(s):
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Guanghua Xiao*+ and Xinlei Wang and Arkady Khodursky
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Companies:
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The University of Texas Southwestern Medical Center at Dallas and Southern Methodist University and The University of Minnesota
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Address:
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5323 Harry Hines Blvd, Dallas, TX, 75019,
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Keywords:
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Gene expression ; Bayesain Spatial ; Chromosome location
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Abstract:
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Recently, many genomic studies have shown that significant chromosomal spatial correlation exist in gene expression of many organisms. Such correlation might be caused by a folding structure of the chromosome in the 3 dimensional space of a cell, which tends to bring functionally related genes that may be far apart along the chromosome chain, into close physical proximity to facilitate their biological functions. We developed a novel Bayesian method to account for chromosomal spatial correlation associated with 3D chromosome structures.
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