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Activity Number:
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439
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #305401 |
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Title:
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Detecting Schizophrenia Liability in Healthy First-Degree Relatives of Schizophrenics: A Finite Mixture Model Approach
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Author(s):
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Charity J. Morgan*+ and Deborah L. Levy and Mark F. Lenzenweger and Donald B. Rubin
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Companies:
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The University of Alabama at Birmingham and McLean Hospital and State University of New York at Binghamton and Harvard University
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Address:
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RPHB 443, Birmingham, AL, 35294-0022,
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Keywords:
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schizophrenia ; mixture models ; zero inflation
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Abstract:
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Psychologists have identified a number of traits that are associated with schizophrenia and that aggregate in relatives of schizophrenics at a rate much higher than that of the clinical disorder. These traits may be alternative manifestations of schizophrenia. The presence of alternative manifestations may help to identify healthy relatives who have inherited one or more of the genes that increases susceptibility for schizophrenia. One of these traits is thought disorder with "schizophrenic" features. We apply finite mixture models to a sample of normal controls and clinically unaffected first-degree relatives of schizophrenic patients and evaluate the suitability of thought disorder as a potential addition to the schizophrenia phenotype.
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