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Activity Number:
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470
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Type:
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Contributed
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Date/Time:
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Wednesday, August 5, 2009 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #305114 |
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Title:
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A Generalized Sequential Bonferroni Procedure for Genome-Wide Association Studies Incorporating Information of Hardy-Weinberg Disequilibrium
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Author(s):
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Guolian Kang*+ and Guimin Gao
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Companies:
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The University of Alabama at Birmingham and The University of Alabama at Birmingham
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Address:
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1665 University Blvd, Birmingham, AL, 35294,
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Keywords:
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generalized sequential Bonferroni procedure ; Hardy-Weinberg disequilibrium ; weights ; multiple testing ; genome-wide association studies
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Abstract:
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In genetic case-control studies, association between a marker and disease is often assessed by allelic association test (AAT). In addition, methods based on information of Hardy-Weinberg disequilibrium (HWD) have been developed as tools for detecting genetic association. In genome-wide association studies (GWAS), hundreds of thousands of single nucleotide polymorphisms (SNPs) are being tested by AAT or a test based on HWD, the power is low if Bonferroni procedure is used to control family-wise error rates (FWERs). To increase power of GWAS, we apply generalized sequential Bonferroni (GSB) procedure to GWAS by using AAT and calculating weight for test at each marker using information of HWD. Simulations show that our method controls FWERs well and can improve power of GWAS significantly in some situations. The application of our method to a genomwide real dataset confirms its performance.
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