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Activity Number: 56
Type: Topic Contributed
Date/Time: Sunday, August 2, 2009 : 4:00 PM to 5:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #304220
Title: Contributions of different design components to the efficiency of an adaptive design in dose ranging studies
Author(s): Vladimir Dragalin*+
Companies: Wyeth Research
Address: 500 Arcola Road, Collegeville, PA, 19426,
Keywords: adaptive design ; dose ranging studies ; longitudinal model ; response-adaptive allocation ; stopping rule ; operating characteristics
Abstract:

PhRMA Working Group on Adaptive Dose Ranging Studies is considering a set of new adaptive designs, based on both frequentist and Bayesian methodology. We will present the results of a comprehensive simulation study that compares the contributions of different design components such as working model for efficacy dose response relationship, response adaptive allocation, number of doses, stopping rules, frequency of interim analyses, longitudinal model, etc on performance (operating characteristics) of these new designs.

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Revised September, 2008