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Activity Number:
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359
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303949 |
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Title:
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Two-Stage Procedures for Selecting the Best Diagnostic Biomarkers
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Author(s):
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Aiyi Liu*+
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Companies:
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National Institute of Child Health and Human Development
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Address:
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, , MD, 20852,
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Keywords:
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classification rate ; diagnosis ; nuisance parameters ; probability of correct selection ; sensitivity ; specificity
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Abstract:
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We consider the problem of selecting a diagnostic biomarker that has the best diagnostic accuracy among several candidate markers with dichotomous outcomes. The probability of correct selection of the best biomarker depends on a number of nuisance parameters from the joint distribution of the biomarkers and thus can be substantially affected if these nuisance parameters are misspecified. A two-stage procedure is proposed to compute the needed sample size that achieves the desired level of correct selection, as so confirmed by simulation results.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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