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Activity Number:
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17
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Type:
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Topic Contributed
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Date/Time:
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Sunday, August 2, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #303816 |
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Title:
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Propensity Scores in Observational Studies
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Author(s):
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Michael Gaffney*+ and Jack Mardekian
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Companies:
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Pfizer Inc. and Pfizer Inc.
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Address:
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235 East 42 Street, New York, NY, 10017,
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Keywords:
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Observational ; Propensity ; Confounding
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Abstract:
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The use of observational databases to compare the safety and efficacy of different treatment modalities is becoming more frequent. The lack of randomization in observational studies likely leads to confounding in estimating the treatment effect. Propensity scores is a method that has been developed to address the problem of confounding in the analysis of observational studies. This talk will use an actual example to illustrate important features of propensity score analysis. Topics to be addressed are the use of propensity scores in a multivariate regression model and as a means of stratification and matching. Principals of developing a propensity score, evaluating the utility of a propensity score and the relationship to multivariate regression will also be addressed.
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