From Constructing the Age-Specific Reference Range to the Disease Outcome Study

• Activity Number: 380
• Type: Contributed
• Date/Time: Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
• Sponsor: Biometrics Section
• Author(s): Chong Y. Fu*+ and Ya-Wen Yang and Hsin-Yi Huang and Shih-Hua Liu
• Companies: National Yang Ming University and National Yang Ming University and National Yang Ming University and National Yunlin University of Science & Technology
• Keywords: age reference range ; regression mean ; normalization ; threshold distribution

Abstract

An age specific reference range (ARR) is essential in clinical medicine. The methodology usage is commonly from regression mean. The residual diagnosis and data transformation are employed repeatedly in the process of constructing ARR. Based on final normal distribution of residual the ARR will been constructed. This study illustrates the construction of reference range relating gestational age, for UMBAPI, DVPIV and NBL. And, the results will further link to outcome studies. The residual normal distribution can be treated as a threshold distribution of some measurement (e.g., UMBAPI, DVPIV or NBL). Thus, beyond the threshold value disease (outcome) presents, otherwise disease ansent. This is an aggregate method from constructing ARR to link with disease outcome and highlight a threshold concept relating medicine or biology.