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Activity Number:
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452
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Type:
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Invited
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Date/Time:
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Wednesday, August 5, 2009 : 10:30 AM to 12:20 PM
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Sponsor:
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IMS
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| Abstract - #303244 |
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Title:
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Problems Resulting from the Avalanche of Genetic Information
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Author(s):
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Robert C. Elston*+
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Companies:
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Case Western Reserve University
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Address:
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2103 Cornell Road, Cleveland, OH, 44106,
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Keywords:
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Abstract:
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The paradigm for finding genes underlying complex diseases is changing from linkage analysis to association analysis, often with a corresponding change in the design of studies from the collection of segregating families to the relatively inexpensive collection of presumed unrelated cases and controls. At the same time, advances in molecular technology have made it feasible to perform hundreds of thousands of tests of debatable accuracy more cheaply than ever before. This requires automation of the analyses, which can lead to the generation of unprecedented numbers of type 1 and type 2 errors. True results may not be replicated and/or false results may be replicated when software is used that does not perform diagnostic tests for assumptions, or when the user ignores any such tests that are performed. The challenge to produce fast intelligent software is hardly being met.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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