JSM Preliminary Online Program
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Activity Number: 543
Type: Invited
Date/Time: Thursday, August 6, 2009 : 8:30 AM to 10:20 AM
Sponsor: SSC
Abstract - #303227
Title: Current Issues in Genome-Wide Association Studies of Complex Traits
Author(s): Shelley B. Bull*+ and Lei Sun
Companies: Samuel Lunenfeld Research Institute of Mount Sinai Hospital and University of Toronto
Address: Dalla School of Public Health, Toronto, ON, M5T 3L9, Canada
Keywords: statistical genetics ; genome-wide association ; multiple testing
Abstract:

Investigators in human genetics have begun to elucidate the factors influencing genetic susceptibility to common complex diseases such as cardiovascular disease, diabetes, infectious disease, and cancer. With decreasing genotyping costs, studies in relatively large numbers of individuals are now feasible. At present, data arising from genome-wide association studies (GWAS) of 1M genetic markers are at hand, with the attendant issues of multiple testing, valid effect estimation, and replication study design. These studies have given strong impetus to develop new statistical approaches tailored to the complex structure inherent in genetic variation in human populations. In this talk I will review GWAS examples that illustrate some current issues and developments in modeling and inference. Joint work with Lei Sun, Yun Joo Yoo, Laura Faye, Daryl Waggott, and Andrew Paterson.

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