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Activity Number:
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342
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Type:
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Invited
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Date/Time:
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Tuesday, August 4, 2009 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Bayesian Statistical Science
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| Abstract - #303120 |
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Title:
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The Role of Meta-Analysis in Assessing Adverse Drug Effects
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Author(s):
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Joel B. Greenhouse*+
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Companies:
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Carnegie Mellon University
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Address:
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Department of Statistics, Pittsburgh, PA, 15213,
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Keywords:
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Meta-Analysis ; Sensitivity Analysis
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Abstract:
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Meta-analysis is an essential methodology for synthesizing evidence, particularly in the biomedical and social sciences. Quantitative research synthesis is frequently used to accumulate evidence about questions of interest; it can also be used to investigate the generalizability of research results, and to investigate alternative explanations for observed associations. In this talk, we discuss the role of meta-analysis in the assessment of drug safety considerations and consider the strengths and weaknesses of evidence generated from research synthesis. As a case study to help illustrate some of these issues, we consider the evidence from a meta-analysis of randomized controlled trials that the FDA used to inform their decision to issue a black box warning concerning the risk of suicidality in children who use antidepressants.
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