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This is the preliminary program for the 2008 Joint Statistical
Meetings in Denver, Colorado.
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The views expressed here are those of the individual authors and not necessarily those of the ASA or its board, officers, or staff. Back to main JSM 2008 Program page |
= Applied Session,
= Theme Session,
= Presenter|
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| CE_17C | Mon, 8/4/08, 8:30 AM - 5:00 PM | CC-205 |
| Statistical Evaluation of Medical Tests and Biomarkers for Classification - Continuing Education - Course | ||
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ASA, Section on Statistics in Epidemiology |
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| Instructor(s): Margaret S. Pepe, Fred Hutchinson Cancer Research Center, Holly Janes, Fred Hutchinson Cancer Research Center, Todd A. Alonzo, University of Southern California | ||
| Development of biomarkers and medical diagnostic devices has accelerated. Their rigorous evaluation is a high priority for research, yet principles and techniques for the design and analysis of these studies are not widely known. There are fundamental differences among methods for therapeutic and etiologic studies. Moreover, much basic methodology has developed recently. We will cover estimation and comparison of Receiver Operating Characteristic (ROC) curves and describe extensions to adjust for covariates that affect biomarker/test measurements. For assessing factors associated with test performance, ROC regression methods will be presented. We also will consider how to evaluate the benefit of a new test when standard tests or clinical variables exist. Second, we will consider the design of case-control studies most common in this field. Sample size calculations and optimal choice of case-control ratio will be presented and the attributes and limitations of matching controls to cases will be discussed. Third, prospective studies will be considered. Finally, we will discuss problems incurred when the gold standard reference test is, itself, subject to error. A suite of freely available Stata programs will implement analyses. Prerequisite: introductory statistics. | ||
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JSM 2008
For information, contact jsm@amstat.org
or phone (888) 231-3473. If you have questions about the Continuing Education program,
please contact the Education Department. |