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This is the preliminary program for the 2008 Joint Statistical
Meetings in Denver, Colorado.
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The views expressed here are those of the individual authors and not necessarily those of the ASA or its board, officers, or staff. Back to main JSM 2008 Program page |
= Applied Session,
= Theme Session,
= Presenter|
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| CE_08C | Sun, 8/3/08, 8:30 AM - 5:00 PM | CC-203 |
| Modern Practical Bayesian Clinical Trial Design - Continuing Education - Course | ||
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ASA, Section on Bayesian Statistical Science |
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| Instructor(s): Peter F. Thall, The University of Texas M.D. Anderson Cancer Center, J. Kyle Wathen, The University of Texas M.D. Anderson Cancer Center | ||
| We will cover practical Bayesian methods for clinical trial design and conduct. Attendees should have a master's degree in statistics, or equivalent experience, and an understanding of elementary Bayesian concepts. There will be numerous illustrations using actual clinical trials. Drawn from oncology, examples will include methods for eliciting and calibrating priors, incorporating historical data, and using computer simulation to establish a design's frequentist properties. The morning will cover phase I designs-including dose-finding using the continual reassessment method and logistic regression, finding optimal dose pairs of a two-agent combination, and accommodating multiple toxicities-and phase II designs, including a paradigm for monitoring multiple discrete outcomes, randomized phase II trials, monitoring event times, hierarchical Bayesian methods for trials with multiple disease subtypes, and using regression to account for patient heterogeneity. The afternoon will cover phase I/II dose-finding based on efficacy-toxicity trade-offs, optimizing schedule of administration, jointly optimizing dose and schedule, adaptive randomization, a geometric approach to treatment comparison based on two-dimensional parameters, and designs to evaluate multistage dynamic treatment regimes. | ||
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JSM 2008
For information, contact jsm@amstat.org
or phone (888) 231-3473. If you have questions about the Continuing Education program,
please contact the Education Department. |