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Activity Number:
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331
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Type:
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Roundtables
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Date/Time:
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Wednesday, August 6, 2008 : 7:00 AM to 8:15 AM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #302082 |
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Title:
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Methods for Assessing Exposures to Mixtures of Chemicals
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Author(s):
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Enrique F. Schisterman and Rajeshwari Sundaram*+ and Amy H. Herring
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Companies:
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National Institute of Child Health and Human Development and National Institutes of Health and The University of North Carolina at Chapel Hill
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Address:
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6100 Executive Blvd., Rockville, MD, 20852,
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Keywords:
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study design ; correlated exposure ; toxicology ; mixtures
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Abstract:
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While laboratory studies are often designed to evaluate effects of single chemical exposures, most human populations are exposed to mixtures of a variety of known and potential toxins. Study of toxicity of environmental agents whose quantification may be mixtures is complex. Much current work focuses on only a parent compound, a common metabolite, or a summary measure calculated over a class of compounds. Interesting issues for both study design and analysis include disentangling single-chemical versus multiple-chemical effects, measurement error, and limit of detection issues. We will discuss new study design and analysis methods for both laboratory and epidemiological studies that may advance our understanding of health effects of exposures to mixtures of chemicals.
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