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Activity Number: 188
Type: Contributed
Date/Time: Monday, August 4, 2008 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Epidemiology
Abstract - #301917
Title: Sampling Issues in Biomarker Studies of Nevus Phenotypes
Author(s): Jaya M. Satagopan*+
Companies: Memorial Sloan-Kettering Cancer Center
Address: 307 East 63rd Street, New York, NY, 10021,
Keywords:
Abstract:

The etiologic effects of complex traits are often conferred by multiple risk factors. Cancer epidemiology studies typically establish a large cohort to study risk factors for complex diseases and disease phenotypes. While some putative risk factor data are obtained from the full cohort, new risk factors such as biomarkers need to be constantly examined as studies continue. Evaluating the biomarkers on the full study cohort may not always be feasible due to logistic or economic concerns. Therefore, it may be useful, or sometimes necessary, to identify an informative sub-cohort for evaluating new risk factors in an efficient manner. This talk examines a novel stratification scheme for identifying an informative sub-cohort for biomarker evaluation. Our work is motivated by the ongoing Study of Nevi in Children the investigates risk factors associated with nevogenesis and nevus evolution.


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Revised September, 2008