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Abstract:
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A current trend within in vitro chemotherapy studies is to combine two or more existing drugs in hopes that the mixture will be synergistic. We are specifically interested in determining whether or not three fruit enzymes act synergistically in combination; that is, whether or not the response to the combination is greater than expected under some chosen model of noninteraction. In order to identify synergy, one must establish a mathematical model for noninteraction with which to compare. Because these agents are believed to function via different direct mechanisms, the models of independence and effect summation are considered most appropriate. In addition, the agents of interest have been studied extensively. Thus, Bayesian methods will be presented, including operational characteristics comparing results from the two models for several prior structures.
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