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Activity Number:
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188
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Type:
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Contributed
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Date/Time:
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Monday, August 4, 2008 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #301256 |
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Title:
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The Exposure-Controlled Retrospective Study: Application to High-Incidence Diseases
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Author(s):
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Peng T. Liu*+
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Companies:
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U.S. Food and Drug Administration
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Address:
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5100 Paint Branch Pkwy, College Park, MD, 20740,
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Keywords:
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Alternative Design ; High Incidence ; Case-Control Study ; Sample Size ; Relative Efficiency
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Abstract:
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For measuring the degree of association between a disease and a risk factor, we have developed a new epidemiological design that can serve as an alternative to the conventional design for cohort and case-control studies. When the prevalence rate of disease is greater than the prevalence rate of exposure, this new design is superior in terms of the sample size and of the efficiency of estimate. A "reversed weighting" procedure is adopted for estimating the required sample size. The relative efficiency of the new design in comparison with case-control study results under a wide variety of conditions is also examined.
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