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Activity Number:
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43
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Type:
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Invited
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Date/Time:
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Sunday, August 3, 2008 : 4:00 PM to 5:50 PM
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Sponsor:
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IMS
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| Abstract - #300369 |
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Title:
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Opportunities and Challenges of Whole-Genome Association Studies
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Author(s):
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David Siegmund*+
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Companies:
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Stanford University
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Address:
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Sequoia Hall, Stanford , CA, 94305,
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Keywords:
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association ; genome ; linkage
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Abstract:
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A unified framework for association studies and for linkage studies will be described. It will be shown that although one expects association studies to have substantially more power than linkage studies, standard statistics to test for association are less robust to modeling errors, so there can be a significant loss of power if one fails to include dominance or gene-gene interaction in the model. For approximating significance levels, simple improvements on the Bonferroni bound and on the central limit theorem will be discussed.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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