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Activity Number:
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286
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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ENAR
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| Abstract - #309043 |
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Title:
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Comparing Various Designs of Temporal Microarray Experiments
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Author(s):
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Yijun Yang*+ and Paola Sebastiani
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Companies:
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Boston University and Boston University
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Address:
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16 Walnut St Apt 42, Arlington, MA, 02476,
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Keywords:
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time series ; gene expression ; clustering
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Abstract:
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Common temporal gene expression studies consist of a number of unevenly spaced observations that are often replicated to average out biological and sampling variability. Due to the high cost of microarray experiments, duplication of the same time point experiments are often chosen at the price of the sampling frequency. The sampling frequency is important to capture the essential dynamics of the data generation process and to increase the power to identify interesting genes with similar expression profiles. We conducted a simulation study to investigate the effect of replicating microarray experiments compared to increasing the sampling frequency, and we determined the minimum number of time points for recovering true number of clusters. CAGED (cluster analysis of gene expression dynamics) was used for clustering the simulated gene expression data.
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