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Activity Number:
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62
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Type:
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Topic Contributed
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Date/Time:
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Sunday, July 29, 2007 : 4:00 PM to 5:50 PM
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Sponsor:
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WNAR
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| Abstract - #310358 |
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Title:
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Some Statistical Issues in Rheumatology
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Author(s):
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Charlie Goldsmith*+
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Companies:
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McMaster University
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Address:
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Centre for Evaluation of Medicines, Hamilton, ON, L8N 1G6, Canada
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Keywords:
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Design ; Factorial ; Measurement ; Outcome ; Validity ; Trials
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Abstract:
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The rheumatic diseases have interesting statistical design issues and innovations in measurement methodology. These include use of experimental designs such as extra-period Latin Squares, Latin Squares, factorial designs and new fractional factorial designs to estimate efficacy when a placebo group is unethical. The Central Limit Theorem has been adapted to make better outcome measurement tools and the recognition of bias in outcome assessment has lead to the development of an "Independent Assessor" as a trained measurer, but not a health professional who is biased in the assessment of these patients; and validating Nurse Measurers to replace Rheumatologists in clinical trials. The innovations have led to improvements in measurement methods and tools that have allowed researchers to become more efficient in the assessment of therapies that can help patients with these diseases.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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