JSM Preliminary Online Program
This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 296
Type: Roundtables
Date/Time: Tuesday, July 31, 2007 : 12:30 PM to 1:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #310288
Title: Estimation of Treatment Effects in Randomized Trials with Noncompliance and Crossover: Why ITT Analysis May Not Be Our Best Option
Author(s): Afisi S. Ismaila*+ and Stephen Walter
Companies: McMaster University and McMaster University
Address: Clinical Epidemiology and Biostatistics, Hamilton, ON, L8S 4L8, Canada
Keywords: Randomized controlled trials ; compliance ; efficacy ; treatment preference
Abstract:

When there are departures from assigned treatments in a randomized controlled trial (RCT), researchers are faced with the problem of estimating treatment benefits in compliant and cross-over patients while respecting randomization. We will discuss why some of the well-known traditional approaches may not be our best option. We also will discuss some of the newest approaches for dealing with this problem.

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Revised September, 2007