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This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 274
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2007 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #310195
Title: Examination of Concentration Effect Modeling of QT Interval from a Statistical Perspective
Author(s): Brian Smith*+
Companies: Amgen Inc.
Address: One Amgen Center Drive, Thousand Oaks, CA, 91320,
Keywords: QT interval ; Concentration effect modeling ; Intersection-Union Method
Abstract:

Concentration effect modeling has been proposed as a more powerful alternative to the currently frequently used intersection-union approach. This talk will examine both methods with an aim of showing when and if concentration effect modeling can be safely used to make decisions regarding a molecule's effect on QT interval.

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Revised September, 2007