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This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 369
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract - #309953
Title: Statistical Issues in Analyzing the Data from Crossover Designed Studies with Carryover Effects-A Monte Carlo Study
Author(s): Ling Chen*+ and Jinglin Zhong and Ferrin D. Harrison
Companies: Food and Drug Administration and Food and Drug Administration and Food and Drug Administration
Address: 10903 New Hampshire Ave., Silver Spring, MD, 20993,
Keywords: carryover effect ; crossover design ; Monte Carlo study ; treatment difference
Abstract:

Some of clinical trials such as drug abuse potential studies, QTc studies, Palatability studies, and feasibility studies with medical tapes, often use Williams square balanced crossover design. In those studies, there may be carryover effects, dropouts may break the balance of the design, and models may be misspecified. We conducted a Monte Carlo Study to examine the performance of the SAS Proc Mixed procedure with carryover effects and/or the dropouts. The results will be reported in this presentation.

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Revised September, 2007