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Activity Number: 467
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
Sponsor: Section on Bayesian Statistical Science
Abstract - #309924
Title: Decision Analysis in Support of Clinical Trial Protocol Decisions
Author(s): Joseph Kahn*+
Companies: Novartis Pharmaceuticals
Address: 320 South Street 17F, Morristown, NJ, 07960,
Keywords: Decision Analysis ; Adaptive design ; Bayesian ; Clinical ; Trial ; Protocol
Abstract:

Presentation will illustrate via a case study for a phase IIa/b adaptive program design how modelers can use decision analysis and Bayesian modeling to more productively assist clinical teams with protocol decisions. Topics include framing and developing a manageable set of compelling alternatives, assuring information is relevant and has credence, salient value measures, analytic methods useful for implementation, and achieving buy-in from both clinical teams and colleagues in statistics.

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Revised September, 2007