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Activity Number: 458
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #309903
Title: Comparison Between Hierarchical Model and Power Prior Approach in a Bayesian Noninferiority Trial Design
Author(s): Peter Lam*+ and Alan Yu and Ming-Hui Chen
Companies: Boston Scientific Corporation and Boston Scientific Corporation and University of Connecticut
Address: 100 Boston Scientific Way, Marlborough, MA, 01752,
Keywords: Non-Inferiority ; Hierarchical Model ; Power Prior ; Simulation
Abstract:

Power prior can be a good alternative to commonly used hierarchical approach in Bayesian study design utilizing historical data. Study designs by these two approaches are presented. Differences, similarities, theoretical link and relations between these two approaches are discussed.

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Revised September, 2007