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Activity Number: 373
Type: Topic Contributed
Date/Time: Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
Sponsor: Section on Bayesian Statistical Science
Abstract - #309831
Title: Bayesian Sample Size Calculation with Average Length Criterion Using Historical Control Data in Medical Device Trials
Author(s): Liang Li*+ and Ming-Hui Chen and Hong Wang
Companies: Genzyme Corporation and University of Connecticut and Boston Scientific Corporation
Address: BioMedical Operation, Cambridge, MA, 02142,
Keywords: Bayesian ; Sample Size Calculation ; Average Length Criterion ; Historical Data
Abstract:

We used the power prior and average length criterion approaches to the problem of determining the required sample size of binomial parameters for Bayesian noninferiority trial with historical control data. We demonstrate the efficacy of Bayesian-based sample-size determination method with a medical device trial example using Monte Carlo simulation.

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Revised September, 2007