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Activity Number:
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380
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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ENAR
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| Abstract - #309754 |
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Title:
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Cluster-Based Phenotype Construction for Linkage Heterogeneity
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Author(s):
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Cavan Reilly*+
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Companies:
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The University of Minnesota
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Address:
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A460 Mayo Building MMC 303, Minneapolis, MN, 55455,
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Keywords:
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linkage analysis ; locus heterogeneity
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Abstract:
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We describe a method for defining phenotypes for complex diseases that may exhibit locus heterogeneity and we use the method to identify a locus related to asthma susceptibility. Unlike other approaches to locus discovery in the presence of heterogeneity, this method seeks loci that segregate in all or most ascertained families while recognizing that other genes and environmental factors that modify the action of the common gene may vary across families. The method is based on seeking groups of families that differ, between groups, in the way affected individuals express the genotype. Then we use the distance of each individual to the cluster center for his family to define a quantitative trait. This quantitative trait is then subjected to a genome scan using variance components methods. The method is applied to a dataset of 27 families and a novel locus was identified.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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