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Activity Number:
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209
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Statistics in Epidemiology
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| Abstract - #309652 |
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Title:
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A New Measure of Excess Longevity in Families
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Author(s):
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Kenneth Boucher*+ and Richard A. Kerber
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Companies:
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Huntsman Cancer Institute and Huntsman Cancer Institute
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Address:
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2000 Circle of Hope Dr, Salt Lake City, UT, 84112,
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Keywords:
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Familial Excess Longevity ; genetics ; aging
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Abstract:
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In this paper we propose a new measure of longevity in families, Modified Familial Excess Longevity (MFEL), and compare it to Familial Excess Longevity (FEL). Both measures can be readily computed using data from large genealogical databases. Familial Excess Longevity (FEL) is a weighted average of the excess longevity of the genetic relatives of a subject, weighted by the degree of relationship. FEL has been shown to correlate positively with other measures of genetic association, such as the risk of recurrence in siblings. MFEL is a related measure of familial longevity constructed using a simple regression model. The performance of MFEL is shown to be superior when both are evaluated using data from a large genealogical database containing millions of records.
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