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Activity Number:
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471
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309564 |
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Title:
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Propensity Score Application in Historically Controlled Clinical Trials
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Author(s):
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Daniel Reyner*+
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Companies:
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Zimmer, Inc
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Address:
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PO Box 708, Warsaw, IN, 46581-0708,
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Keywords:
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Propensity scoring ; clinical trial ; randomization ; historical control ; prospective ; retrospective
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Abstract:
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Clinical data used to achieve regulatory approval confer a population of historical controls to the study sponsor. Such rich data sources are valuable when planning a new clinical trial. Provided an adequate amount of high quality legacy data is available, such data can provide a historical control for a prospective clinical trial. The method of propensity scoring has appeal in such situations as, in principal, it leads to comparisons which approximate results which would be obtained in randomized active controlled clinical trials. This paper examines the use of propensity scoring in historically controlled clinical trials, and provides results from an application of recommended propensity scoring methods to historically controlled clinical trial data.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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