|
Abstract:
|
The mapping of complex/common traits is an important yet difficult research area. Many common human disorders are believed to be "complex" or multifactorial, meaning that they cannot be attributed to alleles of a single gene or one risk factor. Mapping methodologies that simultaneously inspect disjoint loci are crucial for the success of genes mappings. We consider an alternative method (Lo and Zheng 2002, 2004) proposed recently, using family-trio data and several disease models, followed by a demonstration of applying this method to IBD data. The outcomes of this practice suggested the potentials of this approach in drawing substantially more information, leading to novel scientific findings. The main idea applies more generally than to special genetic problems. If time permits, a general mathematical framework will be introduced.
|
