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Activity Number:
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283
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biometrics Section
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| Abstract - #309409 |
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Title:
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Transformation for the Additive Effect on the Affymetrix Probe Data
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Author(s):
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Fenghai Duan*+
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Companies:
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University of Nebraska Medical Center
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Address:
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984350 Nebraska Medical Center, Omaha, NE, 68198-4350,
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Keywords:
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Affymetrix ; Transformation ; probe
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Abstract:
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The microarray technology enables us to measure the expressions of thousands of transcripts in a single experiment. The raw intensity value of a gene is the measurement of the abundance of the corresponding mRNA. The logarithmic transformation is typically performed to the raw intensity data before any further analysis. Some researches have been conducted to search for other transformation functions, mostly focusing on the variance stabilization. In this study, we were using an Affymetrix dataset to investigate the issue of additivity, which is particular important in summarizing the probe level data. A statistical model was also proposed to accommodate our findings. Our results showed our approaches were useful in the quality assessment, normalization and summarization at the probe level for Affymetrix data.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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