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Activity Number:
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246
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309308 |
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Title:
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A Note on Discrete-Time Survival Model with Application to Vertebral Fracture
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Author(s):
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Hongwei Wang*+ and Weili He and Arvind K. Shah
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Companies:
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Merck & Co., Inc. and Merck & Co., Inc. and Merck & Co., Inc.
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Address:
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PO Box 2000, Rahway, NJ, 07065,
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Keywords:
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discrete-time survival model ; proportion ; power ; vertebral fracture ; surrogate ; sample size
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Abstract:
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The status of many clinical outcomes (binary: 1/0) is assessed only at certain fixed time points with the exact time of occurrence unknown. For example in the treatment of osteoporosis, vertebral fracture is usually adjudicated through the readings of X-Ray films taken periodically. For this type of data, the proportion of patients with at least one incident at study end can be utilized as the endpoint of interest. In addition, the discrete-time survival analysis can be applied to the time to the first event. The performance of these models, in terms of power and necessary sample size, is evaluated analytically and through simulation under parameter settings that are of clinical importance to vertebral fracture trial.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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