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Activity Number:
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502
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 2, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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WNAR
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| Abstract - #309112 |
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Title:
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A Likelihood Method of Estimating Ancestry from Pedigrees
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Author(s):
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Janet Sinsheimer*+ and Christopher Plaisier and Adriana Huertas-Vazquez and Carlos Aguilar-Salinas and Teresa Tusie-Luna and Paivi Pajukanta and Kenneth Lange
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Companies:
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University of California, Los Angeles and University of California, Los Angeles and University of California, Los Angeles and Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City and National Autonomous University of Mexico and University of California, Los Angeles and University of California, Los Angeles
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Address:
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Human Genetics 5357C Gonda, Los Angeles, CA, 90095,
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Keywords:
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ethnic admixture ; statistical genetics ; likelihood ; population structure ; estimation ; genomics
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Abstract:
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We have developed a new likelihood based method of estimating ancestry admixture that uses unrelated individuals or pedigrees. For each founder of a pedigree, the method estimates the likelihood of ancestry in K ancestral populations based on the observed genotypes at ancestry informative markers throughout his/her pedigree. These estimates are then propagated down the pedigree to the nonfounders. By using a likelihood based approach, standard errors of the founders' proportions can be determined and propagated to nonfounders. An individual's ethnic ancestry can be more precisely estimated by using the genotype information available in other family members than compared to just using the individual's genotypes alone.
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