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Activity Number:
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196
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biometrics Section
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| Abstract - #309057 |
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Title:
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Application of Discrimination Method on Combining Gene Expression Data of Kidney Transplant Patients
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Author(s):
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Xiangrong Kong*+ and Kellie J. Archer
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Companies:
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Virginia Commonwealth University and Virginia Commonwealth University
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Address:
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3524 Grove Ave Apt 7, Richmond, VA, 23221,
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Keywords:
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chronic allograft nephropathy ; microarray ; discrimination ; kidney tranplant ; gene expression
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Abstract:
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Chronic allograft nephropathy (CAN) is a major cause of graft loss and morbidity among patients with kidney transplantation. It may be promising to characterize the gene expression pattern of CAN and use it for future prognosis. A few groups of researchers used Affymetrix microarray technology to study the gene expression profile of patients with CAN and identified differentially expressed genes related to CAN. It is of our interest to combine and compare the results from these different studies and find genes commonly predictive of CAN. Microarray experiment data from two studies were obtained upon requests. A discrimination method was applied on the gene expression measurements and used to combine across studies. An informative set of genes were found to be highly predictive of the presence of CAN and more discussions will be presented.
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