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Activity Number:
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471
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Type:
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Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #309056 |
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Title:
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The Range Disparity Distribution and Its Applications
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Author(s):
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Lawrence Marinucci*+ and Tailiang Xie
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Companies:
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Acorda Therapeutics Inc and Brightech International
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Address:
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15 Skyline Drive, Hawthorne, NY, 10532,
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Keywords:
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Range disparity ; Response analysis ; Clinical trial
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Abstract:
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Conventionally, inferential statistics focus on measures of central tendency, e.g. the population mean and variance. Little attention is given to the range of sample distributions, while the range is often associated with exceptional values. Under certain circumstances, effects visible at the ranges of a sample may provide more sensitive and even more meaningful measures of differences between populations than the differences in means. In this paper we introduce a distribution of "range disparity" to describe the probability that a given number of items in one set fall outside the range of all the items in another set on a given measure. It can be used to form statistical inferences from the range differences of two independent samples, irrespective of the underlying population distribution. We will also provide several practical application examples.
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