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This is the preliminary program for the 2007 Joint Statistical Meetings in Salt Lake City, Utah.

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Activity Number: 323
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2007 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #308993
Title: Experimental Design for Assessing the Effect of Bone Density on Mechanical Properties After Vertebroplasty
Author(s): Chul Ahn*+
Companies: Food and Drug Administration
Address: 1350 Piccard Dr, Rockville, MD, 10850,
Keywords: Spinal surgery ; Osteoporosis ; Graeco-Latin Square ; Mixed model ; Experimental Design
Abstract:

This is an experimental design problem regarding spinal surgery to repair fractured vertebral bodies with acrylic cement. The question is how to assign the samples to the various treatment groups and choose the correct statistical model to analyze. The experimenter is injecting cadaver spinal bones with acrylic cement to see how bone density and cement dose affect the mechanical properties. There are 5 treatment groups (positive control, negative control, 5%, 15% and 30% cement fill), and 13 cadavers, each of which has a unique bone mineral density that the experimenter would like to correlate with the response variables. Each cadaver yields 5 thoracic and 5 lumbar vertebrae, and the experimenter wishes to randomly distribute these 10 vertebrae into the 5 treatment groups, since the specific level of each vertebra may affect the mechanical properties.

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Revised September, 2007