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Activity Number: 322
Type: Topic Contributed
Date/Time: Tuesday, July 31, 2007 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract - #308835
Title: The Acquisition and Statistical Analysis of High Temporal Resolution 3D fMRI Data
Author(s): Martin Lindquist*+
Companies: Columbia University
Address: 1255 Amsterdam Ave , MC 4690, New York, NY, 10027,
Keywords: fMRI ; brain ; imaging ; high frequency
Abstract:

In this work we present a new acquisition and analysis technique for performing rapid 3D fMRI. Our acquisition strategy is based on repeatedly sampling a small central region of 3D k-space every 100ms, allowing us to obtain a low spatial resolution image with extremely high temporal resolution (compared to the standard 2000ms). The increased resolution allows one to effectively study the intricacies of the hemodynamic response function (HRF) which allows for accurate estimates of differences in activation timing across the brain. The feasibility and efficiency of the approach is confirmed using data from a visual-motor task. The results indicate that important timing information can be found by studying the initial negative dip. As the dip occurs in a time scale closer to that of the neural activity it may provide more accurate estimates of timing compared to more standard approaches.


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Revised September, 2007