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Activity Number:
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244
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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| Abstract - #308762 |
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Title:
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Group Sequential Designs and Analyses for Clinical Trials Based on a Utility Setting
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Author(s):
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Yi Cheng*+
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Companies:
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Indiana University South Bend
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Address:
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1700 Mishawaka Ave, South Bend, 46634,
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Keywords:
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Bayesian method ; Clinical trial ; Conditional expectation ; Group sequential ; Error rates ; Utility
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Abstract:
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A Bayesian group sequential design is proposed for a comparative two-armed clinical trial using utility. Utility functions are set to address multiple issues: to treat patients in clinical trials more effectively and to learn about the better arms more quickly. Data are cumulated using Bayesian method. At each interim analysis, the decision to terminate or to continue the trial is based on the conditional expected utility. The performance of the proposed design is studied in terms of Bayesian optimality, as well as the frequentist error rates for regulatory settings.
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