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Activity Number:
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134
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Type:
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Topic Contributed
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Date/Time:
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Monday, July 30, 2007 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308321 |
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Title:
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Reparameterization of the Five-Parameter Logistic Dose-Response Curve
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Author(s):
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Jason Liao*+ and Rong Liu
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Companies:
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Merck & Co., Inc. and Merck & Co., Inc.
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Address:
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POBox 4, West Point, PA, 19486,
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Keywords:
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dose response curve ; four parameter logistic ; five parameter logistic ; asymmetry ; assay ; potency
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Abstract:
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Recently, the five-parameter-logistic function (5PL) has been increasing used to model a dose-response curve. The 5PL takes into the curve asymmetry into consideration to overcome the drawback of currently widely used four-parameter-logistic (4PL) function, which could lead to wrong estimates of the important parameters, to poor characterization of the pharmacological pathways and the mechanisms, and to wrong inference of drug-receptor interactions. However, the currently used 5PL form does not have good practical interpretation of these parameters comparing to the currently used 4PL. In this talk, we will re-parameterize the 5PL to match the good parameter interpretations of the 4PL. The re-parameterized new 5PL has better practical interpretations and statistical properties.
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- The address information is for the authors that have a + after their name.
- Authors who are presenting talks have a * after their name.
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