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Activity Number:
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325
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, July 31, 2007 : 2:00 PM to 3:50 PM
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Sponsor:
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IMS
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| Abstract - #308280 |
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Title:
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Detection of eQTL Modules Mediated by Activity Levels of Transcription Factors
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Author(s):
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Wei Sun*+ and Ker-Chau Li and Tianwei Yu
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Companies:
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University of California, Los Angeles and University of California, Los Angeles and Emory University
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Address:
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11130 Rose Ave Apt 403, Los Angeles, CA, 90034,
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Keywords:
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eQL ; gene expression ; transcription factor ; causal analysis ; TF activity
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Abstract:
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Studies of gene expression quantitative trait loci (eQTL) have shown the existence of eQTL hotspot. Two questions of great interest about eQTL hot-spots arise: (1) Which gene is the quantitative trait gene (QTG)? (2) How does a QTG affect expression levels of many genes linked to it? The first question can be answered by biological evidence or statistical methods. The second question is harder to address. One simple situation is that the QTG encodes a transcription factor (TF), which regulates the expression of genes linked to it. However, previous results have shown that TFs are not over-represented in the eQTL hotspots. We consider the scenario that the propagation of genetic perturbation from a QTG to other linked genes is mediated by the TF activity. We develop a procedure to detect the eQTL modules (eQTL hot-spots together with linked genes) that are compatible with this scenario.
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