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Activity Number:
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370
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, August 1, 2007 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #308132 |
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Title:
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Nonlinear Blending: An Alternative to Dosewise Additivity, the Interaction Index, and Bliss Independence
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Author(s):
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John Peterson and Steven J. Novick*+
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Companies:
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GlaxoSmithKline and GlaxoSmithKline
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Address:
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, Research Triangle Park, NC, ,
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Keywords:
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combination drug study ; mixture experiments ; drug synergy
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Abstract:
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Many classical synergy measures were derived under somewhat idealized pharmacological situations. These measures are rather limited relative to the wide variety of response surfaces that occur in practice. The statistical area of "mixture experiments", however, makes use of a concept called nonlinear blending to quantify synergy. Nonlinear blending by its simple nature is well defined for any shaped dose response surface. Drugs with different relative potencies, different effect maxima, or situations of potentiation or coalism pose no problem for nonlinear blending as a way to assess the increased response benefit to be gained by combining two drugs. This paper introduces for the first time the concept dichotomy of weak and strong nonlinear blending, and shows how strong nonlinear blending can be used for determining whether or not to blend compounds for enhanced efficacy.
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- Authors who are presenting talks have a * after their name.
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